What does the research say about Polycomb-marked promoter CpG-island methylation gains?

Polycomb-marked promoter CpG-island methylation gains

There is 1 paper on Polycomb-marked promoter CpG-island methylation gains in aging research: none in people yet, 1 in cells. The newest story, Nov 3, 2026: “Some age-linked DNA marks in organoids did not rely on DNA copying”.

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BRAF showed no clear effect on Polycomb-marked promoter CpG-island methylation gains in mouse cells (BRAFV600E induction compared with control lineages).
“Polycomb-marked promoter CpG-island methylation gains were not induced or accelerated by BRAFV600E”
CellsBRAFV600E induction compared with control lineagescolon organoid
Some age-linked DNA marks in organoids did not rely on DNA copying
bioRxivNov 3, 2026Preprint

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bioRxivNov 3

Some age-linked DNA marks in organoids did not rely on DNA copying

A cell experiment using mouse colon organoids linked gains in certain DNA marks to biological aging rather than activation of a cancer-linked mutation.A cell experiment using mouse colon organoids linked gains in certain DNA marks to biological aging rather than activation of a cancer-linked mutation.

Preprint: animal cell studyMechanisms

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Polycomb-marked promoter CpG-island methylation gains

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Some age-linked DNA marks in organoids did not rely on DNA copying

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