bioRxiv
Some age-linked DNA marks in organoids did not rely on DNA copying
A cell experiment using mouse colon organoids linked gains in certain DNA marks to biological aging rather than activation of a cancer-linked mutation.A cell experiment using mouse colon organoids linked gains in certain DNA marks to biological aging rather than activation of a cancer-linked mutation.
Preprint: animal cell studyMechanisms
Who was studiedSingle stem cell-derived mouse colon organoid clones
What changedAge-linked promoter DNA marks did not accelerate in mutation-activated organoids versus controls and accumulated independently of DNA copying
The catchThe reported comparison manipulated a cancer-linked mutation rather than DNA copying directly