Plasma tissue-type plasminogen activator
1 paper5 findings
- Humans1
Effects
2Amyloid deposition
no changein humans1
1 study
Amyloid deposition
no changein humans1
Plasma tissue-type plasminogen activator has no effect on amyloid deposition in humans.
“No correlation was found with brain FDG metabolism or amyloid deposition.”
Humanscognitively unimpaired adultsbrainn = 155
Frontiers in aging neuroscienceJun 7, 2022
Brain FDG metabolism
no changein humans1
1 study
Brain FDG metabolism
no changein humans1
Plasma tissue-type plasminogen activator has no effect on brain FDG metabolism in humans.
“No correlation was found with brain FDG metabolism or amyloid deposition.”
Humanscognitively unimpaired adultsbrainn = 155
Frontiers in aging neuroscienceJun 7, 2022
Upstream
1Alzheimer's disease
no changein humans1
1 study
Alzheimer's disease
no changein humans1
Alzheimer's disease has no effect on plasma tissue-type plasminogen activator in humans.
“No significant difference was found between ALZ patients and cognitively unimpaired elders (CUE).”
HumansAlzheimer's disease patients compared with cognitively unimpaired eldersplasma
Frontiers in aging neuroscienceJun 7, 2022
Associations
2Global brain volume
downin humans1
1 study
Global brain volume
downin humans1
Plasma tissue-type plasminogen activator is associated with global brain volume in humans.
“Plasma tPA in CUA negatively correlated with global brain volume.”
Humanscognitively unimpaired adultsbrainn = 155
Frontiers in aging neuroscienceJun 7, 2022
Age
upin humans1
1 study
Age
upin humans1
Age is associated with plasma tissue-type plasminogen activator in humans.
“A positive correlation was found between tPA and age in CUA (p < 0.001)”
Humanscognitively unimpaired adultsplasman = 155
Frontiers in aging neuroscienceJun 7, 2022