Plasma N-terminal tau fragment

1. Plasma N-terminal tau fragment is associated with plasma phosphorylated tau in humans.

   “Higher NT1 levels were associated with higher levels of plasma biomarkers, including NULISA-based brain-derived (BD) plasma pTau”

   Humansplasma

   Blood tau fragment linked to cognitive decline in older adults

   Neurology·Oct 21, 2026

More on Plasma phosphorylated tau

1. Plasma N-terminal tau fragment predicts hippocampal volume in humans (Longitudinal B = -42.00, SE = 16.90; cross-sectional B = -264.49, SE = 125.99).

   “NT1 levels were negatively associated with hippocampal volume (B [SE] = -264.49 [125.99], p = 0.036) and predicted longitudinal atrophy”

   Humanslongitudinal associationhippocampus

   Blood tau fragment linked to cognitive decline in older adults

   Neurology·Oct 21, 2026

1. Plasma N-terminal tau fragment is associated with cognitive function in humans (Memory B = -0.17; executive function B = -0.24; language B = -0.21).

   “Aβ moderated the association between elevated NT1 and greater cognitive decline across multiple domains”

   Humansassociation moderated by β-amyloid

   Blood tau fragment linked to cognitive decline in older adults

   Neurology·Oct 21, 2026

1. Plasma N-terminal tau fragment is associated with memory performance in humans (B = -0.25, SE = 0.09).

   “were cross-sectionally associated with worse memory performance (B [SE] = -0.25 [0.09], p = 0.005).”

   Humanscross-sectional associationn = 755

   Blood tau fragment linked to cognitive decline in older adults

   Neurology·Oct 21, 2026

1. Mild cognitive impairment or Alzheimer disease is associated with plasma N-terminal tau fragment in humans (B = 0.09, SE = 0.022).

   “Plasma NT1 levels were elevated in MCI/AD individuals”

   HumansMCI/ADplasman = 755

   Blood tau fragment linked to cognitive decline in older adults

   Neurology·Oct 21, 2026

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