Pgr expression

Biomarker

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Upstream

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Reproductive aging

downin mice1

1 study
  1. Reproductive aging impairs Pgr expression in mice.

    “Aged decidualized uteri exhibited impaired progesterone receptor (PGR) expression and spatial dysregulation and reduced expression of P4-responsive genes.”

    Animalsartificial decidualizationdecidualized uterusfemales

    Aged mice showed less growth of pregnancy-supporting uterine tissue

    Uterine research

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Uterine Research

Aged mice showed less growth of pregnancy-supporting uterine tissue

An experiment in young and aged virgin mice isolated uterine effects from ovarian and embryonic factors and found reduced tissue growth in older animals.An experiment in young and aged virgin mice isolated uterine effects from ovarian and embryonic factors and found reduced tissue growth in older animals.

Mouse studyMechanisms