Periorbital skin age

Periorbital skin age is associated with disease history in humans.

“Periorbital skin age showed significant associations with five out of seven diseases individually, as well as with the PC1 summarizing all disease histories collectively.”

Humansfemalesn = 2,515

Periorbital skin index as a biomarker for biological aging and health status

Frontiers in aging·29 Jan 2026

Periorbital skin age is associated with chronological age in humans (r > 0.7).

“seven models demonstrated strong correlations with actual age (r > 0.7), confirming their predictive reliability.”

Humansfemalesn = 2,515

Periorbital skin index as a biomarker for biological aging and health status

Frontiers in aging·29 Jan 2026