Pathogenic mutations
1 paper1 finding
- Humans1
Upstream
1Paternal age
upin humans1
1 study
Paternal age
upin humans1
Paternal age increases pathogenic mutations in humans (3-5% of sperm).
“results in 3-5% of sperm from middle-aged to older individuals with a pathogenic mutation across the exome.”
Humansspermmales
Sperm sequencing reveals extensive positive selection in the male germline
Nature8 Oct 2025
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