Orientation dispersion index

1. Exercise has no effect on orientation dispersion index in humans.

   “A significant Timepoint x Group interaction was observed for NDI (p = 0.003) but not for ODI (p = 0.785)”

   Human trial8-week remotely delivered multicomponent program vs active controlremotely delivered multicomponent exercisewhite matter8 weeksn = 66

   Physical exercise increases the NODDI-derived neurite density index across white matter tracts in healthy older adults: results from the FIT4BRAIN randomized controlled trial · medRxiv · 4 Sep 2026 · Preprint

Exercise →

1. Chronological age is associated with orientation dispersion index in humans.

   Humanscortico-striato-pallido-thalamic loop white matter tractsn = 104

   Cortico-striato-pallido-thalamic loop: Effects of age on white matter neurite microstructural properties and its spatial gradients · bioRxiv · 24 Aug 2026 · Preprint