Nutrient Variety Index

1. Nutrient Variety Index improves metagenomic clock in humans.

   “Adjusting for caloric intake and NVIs significantly improved clock performance, suggesting that nutrient composition modulates microbiome aging.”

   Humanswhen incorporated alongside caloric intaken = 267

   Diet-informed metagenomic clocks for aging in the Integrative Longevity Omics Study · GSA 2025 abstract · 31 Dec 2025

Metagenomic clock →

1. Nutrient Variety Index is associated with system-specific metabolomic aging clock in humans.

   “We found that several subgroups displayed significant associations with multiple NVIs, particularly those reflecting balanced intake of carbohydrates.”

   Humans

   System-Specific Metabolomic Clocks Reveal Aging Heterogeneity and Links to Diet, Cognition, Mortality · GSA 2025 abstract · 31 Dec 2025

System-specific metabolomic aging clock →