medRxiv
Midlife blood protein patterns linked to Alzheimer’s susceptibility
An observational preprint linked blood protein patterns to future cognitive decline, dementia and Alzheimer’s-related tissue changes across cohorts spanning two decades…An observational preprint linked blood protein patterns to future cognitive decline, dementia and Alzheimer’s-related tissue changes across cohorts spanning two decades of follow-up.
Preprint: cohort studyAlzheimer's disease
Who was studiedUK Biobank participants and independent cohort participants, two decades
What changedBlood protein patterns linked to brain structure predicted future dementia across independent cohorts
The catchThe Alzheimer’s-specific outcome was pathology, a stand-in for clinically diagnosed Alzheimer’s disease