Neural stem/progenitor cell numbers

1. NFE2L2 increases neural stem/progenitor cell numbers in mice.

   “examination of newborn Nrf2 knockout (Nrf2 -/-) mice revealed a lower number of SVZ NSPCs in these animals, when compared to wild-type controls.”

   Animalsshown by knockout compared with wild-type controlssubventricular zone

   Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle-age period

   Aging cell·Apr 20, 2016

More on NFE2L2

1. Older age decreases neural stem/progenitor cell numbers in rats.

   “numbers of nestin(+) neural stem/progenitor cells (NSPCs) near the infarct border area or subventricular zone in 12-month-old SHRs were lower than 3-month-old SHRs at day 3.”

   Animalsspontaneously hypertensive rats after transient focal cerebral ischemiainfarct border area or subventricular zone3 days after ischemia

   Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells After Focal Cerebral Ischemia in Spontaneously Hypertensive Rats

   Cell transplantation·Jan 22, 2016