Network Vulnerability Index

1. Network Vulnerability Index is associated with hippocampal volume in humans (r = -0.455).

   Humanshippocampus

   Neuroimaging Epicenters as Vulnerable Nodes in Plasma p-tau217/Aβ42-Positive Alzheimer's Disease · Research (Washington, D.C.) · 24 Aug 2026

Hippocampal volume →

1. Network Vulnerability Index is associated with tau-PET accumulation in humans (r = 0.547).

   Humansmeta-temporal cortex

   Neuroimaging Epicenters as Vulnerable Nodes in Plasma p-tau217/Aβ42-Positive Alzheimer's Disease · Research (Washington, D.C.) · 24 Aug 2026

tau-PET accumulation →

1. Network Vulnerability Index predicts conversion from mild cognitive impairment to dementia in humans (HR = 1.47, P = 0.004).

   Humansacross continuous Alzheimer's disease spectrum

   Neuroimaging Epicenters as Vulnerable Nodes in Plasma p-tau217/Aβ42-Positive Alzheimer's Disease · Research (Washington, D.C.) · 24 Aug 2026