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Negative BOLD response

Biomarker

1 paper2 findings

Associations

2

Mild cognitive impairment

downin humans1

1 study

  1. Mild cognitive impairment is associated with negative BOLD response in humans (in 17 studies).

    “A significantly reduced magnitude of NBR in some regions of the DMN in healthy aging compared with young participants and individuals with elevated Aβ levels, MCI, and AD compared to healthy aging was found in 57, 12, 17, and 14 studies”

    Reviewcompared to healthy aging

    Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature

    Journal of translational medicineJul 29, 2025

More on Mild cognitive impairment

Alzheimer's disease

downin humans1

1 study

  1. Alzheimer's disease is associated with negative BOLD response in humans (in 14 studies).

    “A significantly reduced magnitude of NBR in some regions of the DMN in healthy aging compared with young participants and individuals with elevated Aβ levels, MCI, and AD compared to healthy aging was found in 57, 12, 17, and 14 studies”

    Reviewcompared to healthy aging

    Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature

    Journal of translational medicineJul 29, 2025

More on Alzheimer's disease

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