Mutation profile

1 paper1 finding

Humans1

Upstream

1

Age

no changein humans1

1 study

Age has no effect on mutation profile in humans.
“Unlike mutation count, the mutation profile is not affected by crypt clonality and is very similar across all ages in individuals with no chemotherapy or radiation treatment.”
Humansin individuals with no chemotherapy or radiation treatmentcolon crypt
Mutation count and mutation profile analyses of single-nucleotide variants in single human colon crypts
bioRxiv : the preprint server for biologyJun 14, 2026Preprint

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bioRxivOct 13

Combining DNA data finds more candidate variants in human brains

The analysis expanded candidates supported by multiple methods by approximately two orders of magnitude compared with overlap between software-generated lists of DNA…The analysis expanded candidates supported by multiple methods by approximately two orders of magnitude compared with overlap between software-generated lists of DNA variants.

Preprint: study in peopleAI & data

medRxivSep 23

Distinct Somatic Mutational Landscapes in Paired Blood and Arterial Tissues in Coronary Artery Disease

Preprint: cohort study of 302 peopleMechanisms

CancersSep 15

Selective Inhibition of DNA Polymerase Proofreading: A Metabolic-Fidelity Mechanism Explains Agent Orange-Associated Myelodysplasia

ReviewMechanisms

NAR CancerSep 8

Motif-centered analyses reveal universal and tissue-specific mutagenic mechanisms operating in the human body

Computational studyMechanisms

Cancer Management and ResearchAug 18

Cross-Cancer Detectability of ctDNA Biomarkers in Asian Populations: Implications for Pan-Cancer Detection

Systematic review of observational studiesCancer

medRxivAug 11

Classical driver mutations are not associated with metachronous lesion risk in patients undergoing post-polypectomy surveillance following removal of conventional adenomas in a bowel screening setting

Preprint: cohort study of 723 peopleBiomarkers

NeuronAug 11

Divergent somatic mutation patterns among human cerebellar neuron types

Cross-sectional study in peopleMechanisms

bioRxivJun 22

Mutation count and mutation profile analyses of single-nucleotide variants in single human colon crypts

Preprint: cross-sectional study of 21 peopleGut and microbiome

Human GenomicsMay 10

Exploring the prognostic role of senescence-related genes in gastric cancer through multi-omics integration and machine learning

Experiments in human cellsGastric cancer

Current Hematologic Malignancy ReportsApr 14

Clonal Signatures of Telomere Biology Disorders

ReviewTelomerase and telomere maintenance