DNA mutation count

Crypt polyclonality increases DNA mutation count in humans.

“Consequently, the DNA mutation count would be inflated, while the variant allele frequency for each variant would be reduced in the cell population of a multi-lineage colon crypt.”

Humanscolon crypt

Mutation count and mutation profile analyses of single-nucleotide variants in single human colon crypts

bioRxiv : the preprint server for biology·Jun 14, 2026Preprint