Signal Transduction and Targeted Therapy
Restoring a cell-surface protein eased lung disease in mice
In experiments involving 24 weeks of cigarette smoke exposure, mice lacking the protein had faster lung-function decline and more inflammation than their normal…In experiments involving 24 weeks of cigarette smoke exposure, mice lacking the protein had faster lung-function decline and more inflammation than their normal littermates.
Mouse studyLung
Who was studiedAdult and aged smoke-exposed mice, 6 months, against mice receiving a control virus
What changedRestoring Muc1 improved lung function in smoke-exposed mice compared with mice receiving a control virus
The catchThe gene therapy lacks immunogenicity and dose-dependent toxicity data