mTORC1 activity

1 paper

Animals1

Latest

5 in 12 months

Frontiers in Nutrition11 Sep

Comparative effects of pea protein vs. dairy proteins (α-lactalbumin and casein) on aminoacidemia, exercise performance, gut microbiota, hormonal responses, neurocognitive function, mood, and metabolic-inflammatory responses in older adults

ReviewInterventions

bioRxiv3 Sep

Hormetic heat shock activates HLH-30/TFEB independently of canonical nutrient-sensing pathways

Preprint: experiments in wormsMechanisms

Advanced Science27 Aug

Impaired Chaperone-Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Experiments in human cellsAutophagy

Experimental Gerontology9 Aug

Aging preserves mTORC1 but attenuates JNK-SMAD2L signaling sensitivity to passive stretch-induced tension development in isolated mouse skeletal muscle

Experiments in animalsJNK signalling

AHA Scientific Sessions 2025 Abstract3 Nov

Cholesterol-Driven Monocyte mTORC1 Activation and Autophagy Suppression in Hypercholesterolemic Patients: A Translational Link to Atherosclerosis

Study in peopleMechanisms

ADA Scientific Sessions 2025 Abstract13 Jun

Muscle mTOR Activation Attenuates Cardiomyopathy and Extends Lifespan in Muscle-Specific IRS1/IRS2 Knockout Mice

Experiments in miceCardiomyopathy

Molecular Neurodegeneration4 Feb

Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD

Experiments in miceCellular senescence

Life Sciences3 Jul

Canagliflozin shares common mTOR and MAPK signaling mechanisms with other lifespan extension treatments

Experiments in miceCanagliflozin

Nature Cell Biology10 Apr

Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing

Experiments in wormsmTOR signalling

Nature Metabolism2 Mar

Lysosomal control of senescence and inflammation through cholesterol partitioning

Experiments in miceCellular senescence