Mitochondrial substitution rates

Lifespan predicts mitochondrial substitution rates in silico.

“long-lived vertebrates showed reduced synonymous and nonsynonymous substitution rates, suggesting lower mtDNA mutation.”

In silicoacross vertebrates using phylogenetic comparative normalization

Lifespan Predicts Mitochondrial Substitution Rates across Vertebrates, but Methodology Matters

Genome biology and evolution·2 Mar 2026