Mitochondrial RNA

1. Mitochondrial RNA induces senescence-associated secretory phenotype (SASP) in mouse cells.

   “mitochondrial RNA (mtRNA) also accumulates in the cytosol of senescent cells, activating RNA sensors RIG-I and MDA5, leading to MAVS aggregation and SASP induction.”

   Cellssenescent cells

   Mitochondrial RNA cytosolic leakage drives the SASP

   Nature communications·15 Dec 2025

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