mtDNA functional impact score

mtDNA functional impact score is associated with connectivity between the dorsal attention and language networks in humans (beta = -0.41, p = 0.0007, AdjR2 = 0.15).

“a greater mtDNA FI score was associated with lower connectivity between the dorsal attention and language networks (beta = -0.41, p = 0.0007, AdjR2 = 0.15)”

Humans

Functional Impact Score of Mitochondrial Variants and Its Relationship With Functional Connectivity of the Brain: Potential Origins of Premature Aging in Young Adulthood

Human brain mapping·1 Jan 2026