Mitochondrial burden

Compensatory hypertrophy of residual cells increase mitochondrial burden in humans.

“Hypertrophic epithelial cells exhibit increased mitochondrial burden, reflected by Tom20 expression, which may initially support metabolic adaptation but ultimately contribute to oxidative stress and functional decline.”

Reviewin hypertrophic epithelial cellschoroid plexus epithelium

Morphological and Molecular Characteristics of Choroid Plexus Epithelium in Aged Brains

International journal of molecular sciences·9 Mar 2026