Microglial burden

1. AAV-M3 decreases microglial burden in mice.

   “while IL-10 expression increased microglial burden, the IL-10 + M3 group showed lower microglial burden, suggesting that M3 can successfully lower microgliosis before disease onset”

   Animalsin presymptomatic SOD1-G93A mice expressing IL-10

   IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis

   Scientific reports·Nov 30, 2020

More on AAV-M3

1. PhenoAge is associated with microglial burden in humans (β = 0.40, p = 0.002).

   “significant positive association with acceleration of one epigenetic clock (termed DNAm PhenoAge) averaged over all five brain regions (β = 0.40, p = 0.002).”

   Humansbrain

   A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

   The European journal of neuroscience·Apr 2, 2022

More on PhenoAge