MetaboHealth score

1. MetaboHealth score decreases photoreceptor segment thickness in humans (β = −0.22 μm, p < 0.05).

   “Both higher MVX and MetaboHealth scores were inversely associated with PS thickness (β = −0.09 μm and β = −0.22 μm, both p < 0.05).”

   Humansretina

   Metabolic vulnerability index and MetaboHealth score as risk factors for age-related macular degeneration in a large-scale prospective cohort

   Journal of translational medicine·18 Feb 2026

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1. MetaboHealth score raises the risk of age-related macular degeneration in humans (HR 1.32, 95% CI 1.20–1.45).

   “and 1.32 (1.20–1.45) for the highest quintiles, respectively.”

   Humanshighest quintilemedian follow-up of 13.66 yearsn = 264,352

   Metabolic vulnerability index and MetaboHealth score as risk factors for age-related macular degeneration in a large-scale prospective cohort

   Journal of translational medicine·18 Feb 2026

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1. human-genetics are associated with MetaboHealth score in humans (h2 = 0.4).

   “showed that the MetaboHealth score is moderately heritable (h2 = 0.4).”

   Humans726 monozygotic and 450 dizygotic twin pairs

   Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport

   Immunity & ageing : I & A·9 Sep 2025

1. MetaboHealth score is associated with lipid and ceramide metabolism in humans.

   “lowered levels of 71 HDL remodeling and cholesterol transport related proteins (e.g. APOA1, APOA2, APOA4, and TETN).”

   Humanscontrasting extreme scoring individualsplasma

   Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport

   Immunity & ageing : I & A·9 Sep 2025

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1. MetaboHealth score is associated with inflammation in humans.

   “The high, poor health related, score associated with 42 increased inflammatory and immune related protein levels (CRP, LBP, HPT)”

   Humanscontrasting extreme scoring individualsplasma

   Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport

   Immunity & ageing : I & A·9 Sep 2025

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