There is 1 paper on mature insulin in aging research: none in people yet, 1 in animals.
1 paper studies it3 more mention it1 finding
See all 4 papers on mature insulin
- Animals1
Upstream
1PAX4
upin animals1
1 study
PAX4
upin animals1
PAX4 induces mature insulin (ectopic expression in vivo).
“these gut-derived cells express key β-cell markers, components of the glucose-sensing machinery, and properly process proinsulin into mature insulin”
Animalsectopic expression in vivogastrointestinal epithelium
Harnessing Gut Endocrine Cell Plasticity to Restore Insulin Production
Cells
Latest
1 paper in 12 monthsCells
Harnessing Gut Endocrine Cell Plasticity to Restore Insulin Production
Experiments in animalsGut and microbiome
ADA Scientific Sessions 2025 Abstract
IL-1 and IL-6 Impair Proinsulin Maturation in Aging Mice via Downregulation of Prohormone Convertases
Experiments in miceIL-1 signaling
Cells
An Insulin Upstream Open Reading Frame (INSU) Is Present in Skeletal Muscle Satellite Cells: Changes with Age
Cross-sectional study in peopleMuscle
Physiological Research
Age-Related Changes in Proinsulin Processing in Normoglycemic Individuals
Cross-sectional study of 761 peopleMechanisms