Maternal epigenetic age acceleration

1. Maternal epigenetic age acceleration is linked with lower gestational length in humans (adjusted for chronological age, parity, education, smoking, BMI) (mean 0.51-day decrease (95% CI - 1.00, - 0.02) to 0.80-day decrease (95% CI - 1.29, - 0.31)).

   “Increasing maternal, but not paternal, epigenetic age acceleration was associated with decreased gestational length for five out of six clocks”

   Humansadjusted for chronological age, parity, education, smoking, BMI

   Parental epigenetic age acceleration and risk of adverse birth outcomes: the Norwegian mother, father and child cohort study

   BMC medicine·Nov 25, 2024

1. Maternal epigenetic age acceleration is linked with a higher risk of spontaneous preterm birth in humans (adjusted for chronological age, parity, education, smoking, BMI).

   “These results were also reflected in an increased risk of spontaneous preterm birth and LGA.”

   Humansadjusted for chronological age, parity, education, smoking, BMI

   Parental epigenetic age acceleration and risk of adverse birth outcomes: the Norwegian mother, father and child cohort study

   BMC medicine·Nov 25, 2024

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