MARBLE
Biomarker1 paper3 findings
- Humans1
Associations
2LATE-NC
upin humans1
1 study
LATE-NC
upin humans1
MARBLE is associated with LATE-NC in humans (β = 0.083, 95% CI [0.053, 0.113]).
Humans
MARBLE: An in vivo MRI marker of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) · Alzheimer's & dementia : the journal of the Alzheimer's Association · 1 Sep 2026
MARBLE predicts LATE-NC in humans (AUC = 0.92).
Humansante mortem intervals between MRI and death of < 3 years
MARBLE: An in vivo MRI marker of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) · Alzheimer's & dementia : the journal of the Alzheimer's Association · 1 Sep 2026
Cognitive function
downin humans1
1 study
Cognitive function
downin humans1
MARBLE is associated with cognitive function in humans (p < 10−4).
Humans
MARBLE: An in vivo MRI marker of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) · Alzheimer's & dementia : the journal of the Alzheimer's Association · 1 Sep 2026