Mallory bodies

1. KRT18 prevents Mallory bodies in mice.

   “Old K18 null mice, however, developed a distinctive liver pathology with abnormal hepatocytes containing K8-positive aggregates.”

   Animalsshown by knockoutliver

   Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates

   The Journal of cell biology·Mar 23, 1998

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