Aging Cell
Immune and scar-related signals cluster in aging mouse hearts
Gene activity maps from 6- and 24-month-old mice pointed to valves and the aorta as major sites of age-related immune and scar-related changes.Gene activity maps from 6- and 24-month-old mice pointed to valves and the aorta as major sites of age-related immune and scar-related changes.
Cross-sectional studyImmune response
Who was studiedMale and female C57BL/6J mice, against other heart regions
What changedImmune and scar-related gene signals were concentrated in heart valves and the aorta rather than other heart regions
The catchOnly 3 mice per sex and age group supported the spatial patterns