Locus coeruleus MRI signal intensity

Biomarker1 paper3 findings

  • Humans1

Associations

3

Estrone-to-estradiol ratio

downin humans1

1 study
  1. Estrone-to-estradiol ratio is associated with locus coeruleus MRI signal intensity in humans.

    Humanslocus coeruleusfemales

    Gene variant linked to lower brain scan signals in women · Alzheimer's research & therapy · 6 Oct 2026

Estrone-to-estradiol ratio →

APOE

downin humans1

1 study
  1. APOE is associated with locus coeruleus MRI signal intensity in humans.

    HumansAPOE ε4 carriers versus non-carrierslocus coeruleusfemales

    Gene variant linked to lower brain scan signals in women · Alzheimer's research & therapy · 6 Oct 2026

APOE →

Female sex

upin humans1

1 study
  1. Female sex is associated with locus coeruleus MRI signal intensity in humans.

    HumansAPOE ε4 non-carriers; female versus malelocus coeruleus

    Gene variant linked to lower brain scan signals in women · Alzheimer's research & therapy · 6 Oct 2026

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Alzheimer's Research & TherapyHumans

Gene variant linked to lower brain scan signals in women

An observational study of 101 adults aged 30–85 without cognitive impairment found no overall sex differences in a small brain region’s signals or…An observational study of 101 adults aged 30–85 without cognitive impairment found no overall sex differences in a small brain region’s signals or activity.