Local brain age

1. SLC6A20 is associated with local brain age in humans.

   “In contrast, the SLC6A20 variant was linked to faster aging across parietal and sensorimotor cortices”

   Humansparietal cortexn = 41,708

   Variations in Transporter Genes are Linked to Region-Specific Patterns of Cortical Brain Aging · GSA 2025 abstract · 31 Dec 2025

SLC6A20 →

1. SLC25A13 is associated with local brain age in humans.

   “The SLC25A13 variant was associated with slower aging in frontal and temporal cortices.”

   Humansfrontal cortexn = 41,708

   Variations in Transporter Genes are Linked to Region-Specific Patterns of Cortical Brain Aging · GSA 2025 abstract · 31 Dec 2025

SLC25A13 →

1. KCNK2 is associated with local brain age in humans.

   “These alleles were linked to faster aging in the cingulate, precuneus, and parietal cortices, brain regions that undergo early atrophy in Alzheimer’s disease (AD).”

   Humanscingulate cortexn = 41,708

   Variations in Transporter Genes are Linked to Region-Specific Patterns of Cortical Brain Aging · GSA 2025 abstract · 31 Dec 2025

KCNK2 →

1. LPAR1 is associated with local brain age in humans.

   “Variants in LPAR1, encoding a receptor regulating actin dynamics, neurogenesis, and white matter integrity, were also linked to decreased LBA in parietal and frontal cortices.”

   Humansvariants in LPAR1parietal and frontal corticesn = 41,708

   Polygenic Nature of Cortical Aging Reveals Cytoskeletal Regulation as a Core Pathway of Resilience · GSA 2025 abstract · 31 Dec 2025

LPAR1 →

1. NUAK1 is associated with local brain age in humans.

   “Variants in NUAK1, a serine/threonine kinase regulating tau phosphorylation and microtubule stability, were associated with widespread decreases in LBA”

   Humansvariants in NUAK1cerebral cortexn = 41,708

   Polygenic Nature of Cortical Aging Reveals Cytoskeletal Regulation as a Core Pathway of Resilience · GSA 2025 abstract · 31 Dec 2025

NUAK1 →