NUAK1

1. NUAK1 is associated with local brain age in humans.

   “Variants in NUAK1, a serine/threonine kinase regulating tau phosphorylation and microtubule stability, were associated with widespread decreases in LBA”

   Humansvariants in NUAK1cerebral cortexn = 41,708

   Polygenic Nature of Cortical Aging Reveals Cytoskeletal Regulation as a Core Pathway of Resilience · GSA 2025 abstract · 31 Dec 2025

Local brain age →