LPAR1

1. LPAR1 is associated with local brain age in humans.

   “Variants in LPAR1, encoding a receptor regulating actin dynamics, neurogenesis, and white matter integrity, were also linked to decreased LBA in parietal and frontal cortices.”

   Humansvariants in LPAR1parietal and frontal corticesn = 41,708

   Polygenic Nature of Cortical Aging Reveals Cytoskeletal Regulation as a Core Pathway of Resilience · GSA 2025 abstract · 31 Dec 2025

Local brain age →