Liver fat fraction

1. Liver fat fraction predicts type 2 diabetes in humans (tAUC 0.71 at 3 years, 0.72 at 5 years).

   Humanstime-dependent ROC analysis at 3 and 5 yearslivermedian follow-up of 4.5 yearsn = 356

   Validation of voxel-based computed tomography liver fat quantification for assessing incident type 2 diabetes risk in a health check-up population · Quantitative imaging in medicine and surgery · 10 Aug 2026

2. Liver fat fraction raises the risk of type 2 diabetes in humans (HR per SD 1.65 (95% CI: 1.05-2.60)).

   Humansadjusted for demographic, anthropometric, and metabolic covariateslivermedian follow-up of 4.5 yearsn = 356

   Validation of voxel-based computed tomography liver fat quantification for assessing incident type 2 diabetes risk in a health check-up population · Quantitative imaging in medicine and surgery · 10 Aug 2026

Type 2 diabetes →

1. Liver fat fraction raises the risk of osteoporosis in humans (OR = 1.345, 95% CI: 1.065 to 1.699).

   Humansin normal-BMI postmenopausal womenfemales

   Liver fat fraction negatively correlates with lumbar BMD in normal body mass index postmenopausal women: mediated by bone marrow fat · Frontiers in endocrinology · 9 Sep 2026

Osteoporosis →

1. Liver fat fraction is associated with lumbar proton density fat fraction in humans (β = 0.335, 95% CI: 0.064 to 0.607).

   Humansin normal-BMI postmenopausal women, adjusted for age, BMI, and visceral fat areabone marrowfemales

   Liver fat fraction negatively correlates with lumbar BMD in normal body mass index postmenopausal women: mediated by bone marrow fat · Frontiers in endocrinology · 9 Sep 2026

Lumbar proton density fat fraction →

1. Liver fat fraction is associated with bone mineral density in humans (β = -0.368, 95% CI: -0.605 to -0.131).

   Humansin normal-BMI postmenopausal women, adjusted for age, BMI, and visceral fat arealumbar spinefemales

   Liver fat fraction negatively correlates with lumbar BMD in normal body mass index postmenopausal women: mediated by bone marrow fat · Frontiers in endocrinology · 9 Sep 2026

Bone mineral density →