Life’s Essential 8 cardiovascular health rating
1 paper3 findings
- Humans1
Upstream
1Dietary Index for Gut Microbiota
mediatesin humans1OR 0.996
1 study
Dietary Index for Gut Microbiota
mediatesin humans1OR 0.996
Dietary Index for Gut Microbiota mediates Life’s Essential 8 cardiovascular health rating in humans (TNIE OR 0.996, 95% CI 0.993–0.999; mediation proportion 5.08%, 95% CI 1.35–8.87%).
“DI-GM partially mediated the association between depression and LE8, the total natural indirect effect was statistically significant”
HumansStatistical mediation of the association between depression and LE8, estimated using counterfactual g-computationn = 18,071
Research Square16 Oct 2026Preprint
Associations
2Dietary Index for Gut Microbiota
upin humans1OR 1.46
1 study
Dietary Index for Gut Microbiota
upin humans1OR 1.46
Dietary Index for Gut Microbiota is associated with Life’s Essential 8 cardiovascular health rating in humans (OR 1.46, 95% CI 1.42–1.51 per 1-point increase in DI-GM).
“each 1-point increase in DI-GM was associated with a 46% increase in the cumulative odds of having a higher LE8 score”
HumansAdjusted for potential confoundersEach 1-point increase in DI-GMn = 18,071
Research Square16 Oct 2026Preprint
Depressive symptoms
downin humans1OR 0.91
1 study
Depressive symptoms
downin humans1OR 0.91
Depressive symptoms are associated with Life’s Essential 8 cardiovascular health rating in humans (OR 0.91, 95% CI 0.90–0.93 per 1-point increase in PHQ-9).
“each 1-point increase in PHQ-9 was associated with a 9% reduction in the cumulative odds of having a higher LE8 score”
HumansAdjusted for potential confoundersEach 1-point increase in PHQ-9n = 18,071
Research Square16 Oct 2026Preprint