1 paper3 findings
Estrone-to-estradiol ratio
downin humans1
Estrone-to-estradiol ratio is associated with LC MRI signal intensity in humans.
“a higher estrone-to-estradiol ratio was associated with lower LC MRI signal intensity among participants older than approximately 56 years in our sample.”
Humanslocus coeruleusfemales
Gene variant linked to lower brain scan signals in women
Alzheimer's research & therapy6 Oct 2026
APOE
downin humans1
APOE is associated with LC MRI signal intensity in humans.
“In addition, female ε4 carriers displayed lower LC MRI signal intensity than female ε4 non-carriers.”
HumansAPOE ε4 carriers compared with non-carrierslocus coeruleusfemales
Gene variant linked to lower brain scan signals in women
Alzheimer's research & therapy6 Oct 2026
Female sex
upin humans1
Female sex is associated with LC MRI signal intensity in humans.
“Among APOE ε4 non-carriers, females exhibited higher LC MRI signal intensity than males, whereas this sex difference was absent in ε4 carriers.”
HumansAPOE ε4 non-carriers; females compared with maleslocus coeruleus
Gene variant linked to lower brain scan signals in women
Alzheimer's research & therapy6 Oct 2026
An observational study of 101 adults aged 30–85 without cognitive impairment found no overall sex differences in a small brain region’s signals or activity.An observational study of 101 adults aged 30–85 without cognitive impairment found no overall sex differences in a small brain region’s signals or activity.