kPCr

1. kPCr is associated with white matter microstructural integrity loss in humans.

   “Higher kPCr was also associated with less microstructural integrity loss in white matter tracts connecting identified gray matter areas (n=598).”

   Humanstracts connecting identified gray matter areasn = 598

   SKELETAL MUSCLE MITOCHONDRIAL FUNCTION AND LONGITUDINAL CHANGES IN BRAIN STRUCTURE · GSA 2024 abstract · 31 Dec 2024

1. kPCr is associated with brain atrophy in humans.

   “Higher in vivo mitochondrial function is associated with less worsening in MRI-derived brain aging and Alzheimer’s disease scores, less brain atrophy in specific gray matter regions”

   Humansespecially primary sensorimotor cortex, temporal white and gray matter, thalamus, occipital areas, cingulate cortex, and cerebellumn = 649

   SKELETAL MUSCLE MITOCHONDRIAL FUNCTION AND LONGITUDINAL CHANGES IN BRAIN STRUCTURE · GSA 2024 abstract · 31 Dec 2024

1. kPCr is associated with MRI-derived brain aging score in humans.

   “higher kPCr was associated with less ventricular enlargement, less worsening in MRI-derived brain aging and Alzheimer’s disease scores, and less regional atrophy”

   Humansadjusted for demographics, PCr deletion, and physical activityn = 649

   SKELETAL MUSCLE MITOCHONDRIAL FUNCTION AND LONGITUDINAL CHANGES IN BRAIN STRUCTURE · GSA 2024 abstract · 31 Dec 2024

MRI-derived brain aging score →