There are 8 papers on isovalerylcarnitine in aging research: 6 observational studies in people, 1 in animals.
8 papers study it6 findings
1 new paper in 30 daysSee all 8 papers on isovalerylcarnitine
“3-dehydrocarnitine and isovalerylcarnitine with HGS were significant after Bonferroni correction with a threshold of P < 1.82 × 10- 4”
- Humans6
- Animals1
- In silico1
Effects
2Muscle function-mass
mediatesin humans1
1 study
Muscle function-mass
mediatesin humans1
Isovalerylcarnitine is linked with muscle function-mass in humans (cis-eQTL of SLC22A5 in skeletal muscle) (mediation proportion 67.6%).
“Isovalerylcarnitine (C5) mediated the causal effect of the cis-eQTL of SLC22A5 in skeletal muscle on MF-M GSEM, with a mediation proportion of 67.6% (FDR-adjusted P < 0.05).”
Humanscis-eQTL of SLC22A5 in skeletal muscleskeletal muscle
Dissecting Immune Mechanisms Underlying Sarcopenia Using Multi-omics Approaches
Calcified tissue international
Grip strength
downin humans1
1 study
Grip strength
downin humans1
Isovalerylcarnitine is linked with worse grip strength in humans (β = -1.51 kg, 95% CI -2.31 to -0.71).
“grip strength: β = -1.51 kg, 95% CI = -2.31~-0.71, PIVW = 2.19 × 10−4”
Humans
Nutrients
Associations
3Sarcopenia
upin humans2OR 4
2 studies
Sarcopenia
upin humans2OR 4
Isovalerylcarnitine is linked with a higher risk of sarcopenia in humans (OR 4.00, 95% CI 1.11-14.52).
“isovalerylcarnitine (sarcopenia: odds ratio [OR] = 4.00, 95% confidence interval [CI] = 1.11~14.52, PIVW = 0.034”
Humans
Nutrients
Isovalerylcarnitine is associated with sarcopenia in humans.
“The level of isovalerylcarnitine (C5) was associated with the presence of sarcopenia and SMI.”
Humansserummalesn = 246
BMC geriatrics
Grip strength
upin humans1
1 study
Grip strength
upin humans1
Isovalerylcarnitine is associated with grip strength in humans (two-sample Mendelian randomization) (P < 1.82 × 10- 4).
“3-dehydrocarnitine and isovalerylcarnitine with HGS were significant after Bonferroni correction with a threshold of P < 1.82 × 10- 4”
Humanstwo-sample Mendelian randomization
BMC geriatrics
High intrinsic aerobic capacity
upin rats1
1 study
High intrinsic aerobic capacity
upin rats1
High intrinsic aerobic capacity is associated with isovalerylcarnitine in rats.
“high aerobic capacity is associated with an accumulation of isovalerylcarnitine in muscle and serum at rest”
Animalsskeletal muscle
GeroScience