Intermediate amyloid burden
Biomarker2 findings
Effects
2DAT extreme-deviation burden
upin humans1
1 study
DAT extreme-deviation burden
upin humans1
Intermediate amyloid burden increases DAT extreme-deviation burden in humans (difference = 0.032, q = 0.044).
Humanscognitively unimpaired with intermediate amyloid burden (10 <= CL < 30) vs amyloid-positive (CL >= 30)
Normative brain models reveal dopamine shifts in early amyloid · bioRxiv · 29 Sep 2026 · Preprint
DAT-enriched right caudal middle frontal functional connectivity deviation scores
downin humans1
1 study
DAT-enriched right caudal middle frontal functional connectivity deviation scores
downin humans1
Intermediate amyloid burden decreases DAT-enriched right caudal middle frontal functional connectivity deviation scores in humans (adjusted difference = −0.582, q = 0.016).
Humanscognitively unimpaired with intermediate amyloid burden (10 <= CL < 30) vs amyloid-positive (CL >= 30)right caudal middle frontal cortex
Normative brain models reveal dopamine shifts in early amyloid · bioRxiv · 29 Sep 2026 · Preprint
DAT-enriched right caudal middle frontal functional connectivity deviation scores →
Latest
1Normative brain models reveal dopamine shifts in early amyloid
In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status…In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status, with an adjusted difference of −0.582.