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IL-18BP

There are 5 papers on IL-18BP in aging research: 2 trials and 2 observational studies in people, 1 in animals. The newest story, Nov 7, 2026: “Two immune proteins linked to later heart failure risk”.

Biomarker

5 papers study it1 more mentions it6 findings

3 new papers in 30 daysSee all 6 papers on IL-18BP

“Analysis of the day 1 protein levels showed that IL-18BP associated with maintenance of strength.”
IL-18 Binding Protein, a biomarker of strength maintenance after surgery but reduced physical performance in age-related sarcopeniaPloS one2026doi:10.1371/journal.pone.0340493
  • Human trial2
  • Humans2
  • Animals1

Associations

6

Left atrial volume index

upin humans1

1 study

  1. IL-18BP is associated with left atrial volume index in humans (At Visit 5).

    “higher IL-18BP was associated with greater LV mass index, LV end-diastolic volume index and larger left atrial volume index”

    HumansAt Visit 5heart57% womens

    Two immune proteins linked to later heart failure risk

    AHA Scientific Sessions 2026 abstract

Incident heart failure

upin humans1

1 study

  1. IL-18BP is associated with incident heart failure in humans After Visit 5.

    “higher PD-L1 and IL-18BP levels were significantly associated with a higher risk of incident HF”

    HumansAfter Visit 5plasma57% womens

    Two immune proteins linked to later heart failure risk

    AHA Scientific Sessions 2026 abstract

More on Incident heart failure

SARC-F score

upin humans1

1 study

  1. IL-18BP is associated with SARC-F score in men, not women (r = 0.389, p = 0.003).

    “IL-18BP was associated with SARC-F in men (r = 0.389, p = 0.003) but not women.”

    Humansin men, not womenmales

    IL-18 Binding Protein, a biomarker of strength maintenance after surgery but reduced physical performance in age-related sarcopenia

    PloS one

Mitochondrial gene expression

downin humans1

1 study

  1. IL-18BP is associated with mitochondrial gene expression in humans.

    “Comparison of circulating IL-18BP with the muscle transcriptome in these patients showed negative enrichment for mitochondrial genes.”

    Humansskeletal muscle

    IL-18 Binding Protein, a biomarker of strength maintenance after surgery but reduced physical performance in age-related sarcopenia

    PloS one

Grip strength

downin humans1

1 study

  1. IL-18BP is associated with grip strength in men, not women (r = -0.314 at baseline; r = -0.446 at 12 months).

    “IL-18BP was negatively associated with grip strength in men but not women, at baseline (r = -0.314, p = 0.014)”

    Humansin men, not womenmales

    IL-18 Binding Protein, a biomarker of strength maintenance after surgery but reduced physical performance in age-related sarcopenia

    PloS one

Strength maintenance after surgery

upin humans1

1 study

  1. IL-18BP is associated with strength maintenance after surgery in humans (day 1 after surgery).

    “Analysis of the day 1 protein levels showed that IL-18BP associated with maintenance of strength.”

    Humansday 1 after surgery

    IL-18 Binding Protein, a biomarker of strength maintenance after surgery but reduced physical performance in age-related sarcopenia

    PloS one

Latest

Dec 2025: 0Jan 2026: 1Feb 2026: 0Mar 2026: 1Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 1Nov 2026: 25 papers in 12 months
AHA Scientific Sessions 2026 Abstract

Two immune proteins linked to later heart failure risk

An observational study of adults assessed at average ages 57 and 75 linked two anti-inflammatory blood proteins to later heart failure hospitalizations.An observational study of adults assessed at average ages 57 and 75 linked two anti-inflammatory blood proteins to later heart failure hospitalizations.

Cohort studyHeart failure
Paper

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