Hyporeflective band thickness

1. Age-related macular degeneration increases hyporeflective band thickness in humans (median 7.8 μm vs 4.3 μm, P < 0.0002).

   “In AMD eyes, the hyporeflective band is hypothesized to be basal laminar deposits (BLamDs) and is thicker within the 3-mm ETDRS circle (P < 0.0002) compared with normal eyes.”

   HumansAMD eyes vs normal eyesretina

   Topographic Measurement of the Subretinal Pigment Epithelium Space in Normal Aging and Age-Related Macular Degeneration Using High-Resolution OCT

   Investigative ophthalmology & visual science·Aug 1, 2024

More on Age-related macular degeneration

1. Subretinal drusenoid deposits are associated with hyporeflective band thickness in humans (P < 0.001).

   “AMD eyes with subretinal drusenoid deposits (SDDs) have a significantly thicker hyporeflective band (P < 0.001) than those without SDDs.”

   HumansAMD eyes with SDDs vs without SDDsretina

   Topographic Measurement of the Subretinal Pigment Epithelium Space in Normal Aging and Age-Related Macular Degeneration Using High-Resolution OCT

   Investigative ophthalmology & visual science·Aug 1, 2024