Hippocampal neural stem cell numbers

1. Noggin increases hippocampal neural stem cell numbers in mice.

   “intracranial delivery of the antagonist Noggin restores hippocampal NSC numbers, neurogenesis, and behavior in SAMP8 mice.”

   AnimalsSAMP8 micehippocampus

   Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology

   Proceedings of the National Academy of Sciences of the United States of America·Oct 23, 2018

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1. Magnesium is associated with hippocampal neural stem cell numbers in mouse cells.

   “elevated Mg(2+) concentrations can maintain or increase the number of cultured hippocampal NSCs.”

   Cellsin vitroMg(2+)cultured hippocampal neural stem cellsElevated extracellular concentrations

   Elevation of Brain Magnesium Potentiates Neural Stem Cell Proliferation in the Hippocampus of Young and Aged Mice

   Journal of cellular physiology·Jan 13, 2016

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