GrimAge EAA

1. GrimAge EAA mediates intrinsic capacity in humans (10.8% composite score).

   “Natural effect models indicated partial mediation of the wealth-IC association by GrimAge EAA for psychology (12.5%), locomotion (11.1%), vitality (33.3%), and the composite score (10.8%).”

   Humanswealth-IC associationn = 1,143

   Wealth, Epigenetic Age Acceleration, and Intrinsic Capacity: A Multidomain Mediation Analysis

   International journal of aging & human development·4 Aug 2026

1. GrimAge EAA is associated with intrinsic capacity in humans.

   “Higher GrimAge EAA was consistently associated with lower IC across domains.”

   Humansn = 1,143

   Wealth, Epigenetic Age Acceleration, and Intrinsic Capacity: A Multidomain Mediation Analysis

   International journal of aging & human development·4 Aug 2026

1. Depression is associated with GrimAge EAA in humans (β, 0.06 [95% CI, 0.02 to 0.10] years; P = .01).

   “Depression was associated with higher GrimAge EAA (β, 0.06 [95% CI, 0.02 to 0.10] years; P = .01) in mothers during pregnancy”

   Humansin mothers during pregnancy

   Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns

   JAMA network open·1 Aug 2024

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1. Adverse childhood experiences are associated with GrimAge EAA in humans (β, 0.22 [95% CI, 0.12 to 0.33] years; P < .001).

   “Pregnant women with higher ACE scores exhibited higher GrimAge EAA (β, 0.22 [95% CI, 0.12 to 0.33] years; P < .001).”

   Humansin mothers during pregnancy

   Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns

   JAMA network open·1 Aug 2024

More on Adverse childhood experiences