GM1 ganglioside

1. AAV9-MBGAL decreases GM1 ganglioside in mice (36-76% reduction).

   “36-76% reduction in GM1-ganglioside content in the brain”

   Animalsin adult GM1 mice (βGal(-/-))brain

   Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan

   Human molecular genetics·May 10, 2015

More on AAV9-MBGAL

1. CD8+ T cells increase GM1 ganglioside in mice.

   “In the periphery, CD8+ T cells express significantly higher levels of GM1 than CD4+ T cells.”

   Animalscompared to CD4+ T cells

   Quantitative differences in lipid raft components between murine CD4+ and CD8+ T cells

   BMC immunology·Jan 30, 2004