Glyoxalase I
1 paper2 findings
- Animals1
Upstream
1RYR2
upin mice1
1 study
RYR2
upin mice1
RYR2 increases glyoxalase I in mice.
“found increased GLO1 expression and activity in the PFC and hippocampus as early as 1 month and as late as 21 months of age”
AnimalsS2808D-RyR2 mutant mice exhibiting chronic calcium leak through RyR2prefrontal cortex and hippocampus
JCI insight16 Oct 2025
Associations
1RYR2
upin Macaca1
1 study
RYR2
upin Macaca1
RYR2 is associated with glyoxalase I in Macaca.
“In macaques, we found age-related increases in GLO1 expression in the prefrontal cortex (PFC), correlating with pS2808-RyR2”
Animalsprefrontal cortex
JCI insight16 Oct 2025
Latest
1 in 12 monthsPhysiological Genomics
Systems genomics reveals age- and sex-dependent metabolic dysregulation from Glo1 reduction in mice
Experiments in miceLipid and ceramide metabolism
JCI Insight
Ryanodine receptor 2-mediated calcium leak is associated with increased glyoxalase I in the aging brain
Experiments in monkeysMechanisms