Germline variation

heterochromatin increases germline variation in silico (Z3/Z1 = 1.13).

“Zone 3 vulnerability is constitutional: it is present in healthy germline genomes from 2,504 individuals (Z3/Z1 = 1.13, P = 1.5 × 10−82)”

In silicohealthy germline genomes, n = 2,504n = 2,504

A single formula predicts where cancer mutations and epigenetic aging converge from DNA sequence alone

Zenodo (CERN European Organization for Nuclear Research)·20 Mar 2026Preprint