What does the research say about GenProb-PCa?

GenProb-PCa

There is 1 paper on GenProb-PCa in aging research: 1 observational study in people. The newest story, Nov 2, 2026: “Combined genetic score better distinguishes prostate cancer risk”.

Biomarker

1 paper studies it1 finding

See all 1 papers on GenProb-PCa

“Compared with binary models, GenProb-PCa demonstrated superior discrimination (C-index 0.69 vs 0.52; p<0.001), with significant improvement in reclassification (cNRI 0.58; p<0.001).”

Unified genetic risk score for prostate cancer enables improved risk stratification for clinical decision-makingJournal of medical genetics2026doi:10.1136/jmg-2026-111746

Humans1

Associations

Prostate cancer

upin humans1

1 study

GenProb-PCa predicts prostate cancer in humans (compared with binary models in UKB) (C-index 0.69 vs 0.52).
“Compared with binary models, GenProb-PCa demonstrated superior discrimination (C-index 0.69 vs 0.52; p<0.001), with significant improvement in reclassification (cNRI 0.58; p<0.001).”
Humanscompared with binary models in UKBmalesn = 218,484
Combined genetic score better distinguishes prostate cancer risk
Journal of medical geneticsJul 30, 2026

Latest

1 paper in 12 months

Journal of Medical GeneticsJul 30

Combined genetic score better distinguishes prostate cancer risk

Among 6,590 men, 20% without harmful gene variants moved to higher risk groups and 60% carrying them to lower groups, compared with carrier-only models.Among 6,590 men, 20% without harmful gene variants moved to higher risk groups and 60% carrying them to lower groups, compared with carrier-only models.

Cohort · 218,484 peopleProstate cancer

Paper

GenProb-PCa

Associations

Latest

Combined genetic score better distinguishes prostate cancer risk

Related