Journal of Medical Genetics
Combined genetic score better distinguishes prostate cancer risk
Among 6,590 men, 20% without harmful gene variants moved to higher risk groups and 60% carrying them to lower groups, compared with carrier-only models.Among 6,590 men, 20% without harmful gene variants moved to higher risk groups and 60% carrying them to lower groups, compared with carrier-only models.
Cohort · 218,484 peopleProstate cancer
Who was studied218,484 UK Biobank men without prostate cancer, against carrier-only models
What changedThe combined score better distinguished future prostate cancer cases than carrier-only models: concordance index 0.69 versus 0.52
The catchHealth effects of score-guided screening were not measured