There are 4 papers on gelsolin in aging research: 3 observational studies in people, 1 review.
“higher pGSN levels were associated with lower odds of having contemporaneous phenotypic prefrailty (OR per 1 SD 0.73, 95% CI 0.58-0.92)”
- Humans3
Associations
3Mortality
downin humans1
1 study
Mortality
downin humans1
Gelsolin predicts mortality in humans (HR per 1 SD 0.85, 95% CI 0.72-1.00).
“higher baseline pGSN predicted a lower 7-year mortality rate (HR per 1 SD 0.85, 95% CI 0.72-1.00)”
Humans7 yearsmalesn = 469
Aging clinical and experimental research
Frailty
downin humans1
1 study
Frailty
downin humans1
Gelsolin is associated with frailty in humans (OR per 1 SD 0.70, 95% CI 0.44-1.11).
“and frailty (OR per 1 SD 0.70, 95% CI 0.44-1.11)”
Humansmalesn = 469
Aging clinical and experimental research
Prefrailty
downin humans1
1 study
Prefrailty
downin humans1
Gelsolin is associated with prefrailty in humans (OR per 1 SD 0.73, 95% CI 0.58-0.92).
“higher pGSN levels were associated with lower odds of having contemporaneous phenotypic prefrailty (OR per 1 SD 0.73, 95% CI 0.58-0.92)”
Humansmalesn = 469
Aging clinical and experimental research
Latest
3 papers in 12 monthsmedRxiv
Plasma Proteomics and Sensitive Imaging Biomarkers of Vascular Brain Injury
Preprint: cohort study of 2,586 peopleBiomarkers
Osteoporosis and Sarcopenia
Definition and diagnosis of sarcopenia: Asia-Pacific perspectives
ReviewIndustry & policy
The Journal of Clinical Endocrinology and Metabolism
Vitamin D Binding Protein and Postsurgical Outcomes and Tissue Injury Markers After Hip Fracture: A Prospective Study
Cohort study of 260 peopleHip fracture
Aging Clinical and Experimental Research
Association of plasma gelsolin with frailty phenotype and mortality among octogenarian community-dwelling men: a cohort study
Cohort study of 469 peopleBiomarkers
Frontiers in Endocrinology
SHBG and APOA1 as serum biomarkers for low bone mineral density in Mexican postmenopausal women: a random forest-based analysis
Cross-sectional study of 456 peopleSHBG
Cell Communication and Signaling
Age-related changes in calcium ion influx and efflux capacity of human dermal fibroblasts
Experiments in human cellsMechanisms
ENDO 2025 Abstract
OR04-06 Estrogen Receptor Beta (ERβ) and Gelsolin induced changes in the neuronal transcriptome & proteome
Experiments in human cellsMechanisms
International Journal of Molecular Sciences
Age, Sex Hormones, and Circadian Rhythm Regulate the Expression of Amyloid-Beta Scavengers at the Choroid Plexus
Experiments in animalsMechanisms
Invertebrate Neuroscience
Aging and disease-relevant gene products in the neuronal transcriptome of the great pond snail (Lymnaea stagnalis): a potential model of aging, age-related memory loss, and neurodegenerative diseases
Experiments in model organismsAI & data
Experimental Neurology
The cytoskeleton in 'couch potato-ism': Insights from a murine model of impaired actin dynamics
Experiments in miceMechanisms