What does the research say about FSTL-1?

FSTL-1

There are 3 papers on FSTL-1 in aging research: 2 observational studies in people, 1 in animals.

3 papers study it1 more mentions it2 findings

“lower FSTL-1 concentrations remained significantly associated with an increased likelihood of sarcopenia”

Serum FSTL-1 and AI-assessed muscle parameters in cancer-related malnutritionNutrition (Burbank, Los Angeles County, Calif.)2025doi:10.1016/j.nut.2025.113081

Sarcopenia

upin humans1OR 1.63

1 study

FSTL-1 predicts sarcopenia in humans (AUC 0.69 (95% CI 0.51-0.73)).
“FSTL-1 demonstrated a moderate discriminative capacity for identifying sarcopenia, with an area under the receiver operating characteristic curve of 0.69 (95% CI: 0.51-0.73; P = 0.03)”
Humansn = 91
Serum FSTL-1 and AI-assessed muscle parameters in cancer-related malnutrition
Nutrition (Burbank, Los Angeles County, Calif.)Dec 26, 2025
FSTL-1 is associated with sarcopenia in humans (multivariate logistic regression) (OR = 1.63, 95% CI 1.10-4.21; P = 0.03).
“lower FSTL-1 concentrations remained significantly associated with an increased likelihood of sarcopenia”
Humansmultivariate logistic regressionn = 91
Serum FSTL-1 and AI-assessed muscle parameters in cancer-related malnutrition
Nutrition (Burbank, Los Angeles County, Calif.)Dec 26, 2025