Frailty proteome

Frailty proteome is associated with cardiac and non-cardiac phenotypes and outcomes in humans (N > 35,000, over ≈2-3 decades).

“were associated with cardiac and non-cardiac phenotypes and outcomes across two broad validation cohorts (N > 35,000) over ≈2-3 decades”

Humansn = 35,000

Proteomic architecture of frailty across the spectrum of cardiovascular disease

Aging cell·Sep 20, 2023

Frailty proteome predicts post-intervention outcome in humans.

“Proteomic signatures (specifically of physical function) were related to post-intervention outcome in AS”

Humanssevere aortic stenosis undergoing transcatheter aortic valve implantationn = 809

Proteomic architecture of frailty across the spectrum of cardiovascular disease

Aging cell·Sep 20, 2023